Jochen Schacht Selected Research

Ototoxicity

1/2019	Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
1/2018	Assessing ototoxicity due to chronic lead and cadmium intake with and without noise exposure in the mature mouse.
1/2018	Effects of the 1- N-(4-Amino-2 S-hydroxybutyryl) and 6'- N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics.
1/2017	Histone Deacetylase Inhibitors Are Protective in Acute but Not in Chronic Models of Ototoxicity.
12/2014	Disparities in auditory physiology and pathology between C57BL/6J and C57BL/6N substrains.
11/2014	Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo.
9/2014	Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.
4/2014	Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor.
1/2014	Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases.
11/2012	Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.

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Jochen Schacht Research Topics

Disease

19	Ototoxicity 01/2019 - 05/2002
17	Hearing Loss (Hearing Impairment) 01/2018 - 05/2002
6	Noise-Induced Hearing Loss (Acoustic Trauma) 01/2019 - 07/2003
4	Infections 01/2019 - 03/2003
3	Body Weight (Weight, Body) 11/2014 - 05/2002
3	Cystic Fibrosis (Mucoviscidosis) 04/2014 - 05/2009
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2014 - 05/2009
3	Wounds and Injuries (Trauma) 01/2013 - 11/2004
3	Neoplasms (Cancer) 03/2009 - 05/2002
2	Communicable Diseases (Infectious Diseases) 01/2019 - 09/2014
1	Bacterial Infections (Bacterial Infection) 01/2020
1	Sepsis (Septicemia) 01/2019
1	Leishmaniasis 09/2015
1	Visceral Leishmaniasis (Kala Azar) 09/2015
1	Type 2 Diabetes Mellitus (MODY) 11/2014
1	High-Frequency Hearing Loss 12/2013
1	Sensorineural Hearing Loss 05/2012
1	Deafness (Deaf Mutism) 02/2012
1	Tuberculosis (Tuberculoses) 11/2011
1	Mucopolysaccharidosis I (Hurler Syndrome) 05/2009
1	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 05/2009
1	Usher Syndromes (Usher Syndrome) 05/2009
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2009
1	Necrosis 09/2004
1	Neoplasm Metastasis (Metastasis) 05/2002
1	Breast Neoplasms (Breast Cancer) 05/2002

Drug/Important Bio-Agent (IBA)

20	AminoglycosidesIBA 01/2020 - 05/2002
10	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 02/2004
8	Pharmaceutical PreparationsIBA 01/2019 - 12/2004
7	AntioxidantsIBA 11/2014 - 05/2002
6	Gentamicins (Gentamicin)FDA LinkGeneric 01/2018 - 04/2006
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2015 - 05/2002
4	Cisplatin (Platino)FDA LinkGeneric 11/2012 - 12/2004
3	Paromomycin (Paromomycin Sulfate)FDA LinkGeneric 01/2019 - 09/2014
3	Nonsense Codon (Nonsense Mutation)IBA 04/2014 - 05/2009
3	Free RadicalsIBA 05/2007 - 06/2003
2	apramycinIBA 01/2020 - 07/2012
2	EnzymesIBA 01/2019 - 02/2005
2	Histones (Histone)IBA 01/2017 - 03/2009
2	Kanamycin FDA Link 01/2017 - 06/2003
2	Histone Deacetylase InhibitorsIBA 01/2017 - 03/2009
2	SalicylatesIBA 04/2007 - 05/2002
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 04/2007 - 04/2006
1	propylamycinIBA 01/2019
1	TransferasesIBA 01/2019
1	Heavy MetalsIBA 01/2018
1	plazomicinIBA 01/2018
1	Tobramycin (Nebcin)FDA LinkGeneric 01/2018
1	CadmiumIBA 01/2018
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2017
1	PanobinostatIBA 01/2017
1	belinostatIBA 01/2017
1	Vorinostat FDA Link 01/2017
1	Metformin (Glucophage)FDA LinkGeneric 11/2014
1	Hypoglycemic Agents (Hypoglycemics)IBA 11/2014
1	Proteins (Proteins, Gene)FDA Link 01/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2013
1	Peroxiredoxin IIIIBA 01/2013
1	Small Interfering RNA (siRNA)IBA 01/2013
1	2-deoxystreptamineIBA 07/2012
1	Codon (Codons)IBA 11/2011
1	PeroxidesIBA 04/2011
1	DNA (Deoxyribonucleic Acid)IBA 05/2009
1	tempolIBA 05/2007
1	CreatineIBA 05/2007
1	Free Radical ScavengersIBA 05/2007
1	NF-kappa B (NF-kB)IBA 03/2005
1	Superoxide DismutaseIBA 02/2005
1	Superoxide Dismutase-1IBA 02/2005
1	Superoxides (Superoxide)IBA 02/2005
1	A-factor (Streptomyces)IBA 11/2004
1	Calcineurin InhibitorsIBA 11/2004
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 11/2004
1	CalcineurinIBA 11/2004
1	Tacrolimus (Prograf)FDA LinkGeneric 11/2004
1	Reactive Nitrogen SpeciesIBA 09/2004
1	Oxygen (Dioxygen)IBA 09/2004
1	IsoprostanesIBA 07/2003
1	tanshinoneIBA 06/2003
1	SolutionsIBA 06/2003
1	IonsIBA 03/2003

Therapy/Procedure

6	Therapeutics 01/2019 - 06/2003
1	Drug Therapy (Chemotherapy) 12/2004
1	Injections 06/2003